中国细胞生物学委员，中国老年医学常务委员

主要研究方向： 

（1）干细胞功能调控、衰老及肿瘤发生的机制。 

（2）组织损伤修复及稳态维持的机制。 

（3）个体衰老及肿瘤等衰老相关疾病研究。 

（4）抗衰老及相关疾病药物筛选及其机制研究。 

主持或参与的科研项目: 

国家科技部重点研发项目，2020YFA0803602，调控代谢可塑性和代谢记忆形成的信号通路及表观遗传机制，2020/12-2025/11,主持（课题负责人）。 

国家自然科学基金重大研究计划培育项目，91749110，线粒体Sirtuin4不对称分配介导的干细胞行为对器官衰老的作用和调控机制研究，2018/01-2020/12，主持。 

国家自然科学基金优秀青年项目，31622031，个体衰老的细胞及分子机理研究，2016年，主持。 

国家自然科学基金面上项目，31671254，衰老过程中Lamin-B Receptor蛋白聚积通过扰乱干细胞竞争促进生殖干细胞丢失的分子机制研究，2017/01-2020/12，主持。 

国家科技部重点研发项目，2018YFA0108301，干细胞外泌体调控中枢神经系统功能修复的机制和转化研究，2018/07-2023/06,参与（课题骨干）。 

广东省杰出青年项目，衰老的分子机制研究方向，2016年，生命科学。 

代表性论文（*通讯作者）：

Guo X.#, Zhou J.#, Yan L.#, Liu X., Yuan Y., Ye J., Zhang Z., Chen H., Yongxin Ma Y., Zhong Z., Luo G., and Haiyang Chen H.*.(2024). Very long-chain fatty acids control peroxisome dynamics via a feedback loop in intestinal stem cells during gut regeneration. Developmental Cell, 2024, 59, 1–17, October 7. https://doi.org/10.1016/j.devcel.2024.06.020.

Jinbao Ye#, La Yan#, Yu Yuan#, Fang Fu, Lu Yuan, Xinxin Fan, Juanyu Zhou, Yuedan Zhu, Xingzhu Liu, Gang Ren*, and Haiyang Chen*. Natural flavonoid glycosides Chrysosplenosides I & A rejuvenate intestinal stem cell aging via activation of PPARγ signaling. Life Medicine, 2024, Volume 3, Issue 3, June 2024, lnae025, https://doi.org/10.1093/lifemedi/lnae025.

Zhang Q., Deng K, Liu M., Yang S., Xu W., Feng T., Jie M., Liu Z., Sheng X., and Chen H.*, and Jiang H.* (2023). Phase separation of BuGZ regulates gut regeneration and aging through interaction with m6A regulators. Nature Communication：2023 Oct 23;14(1):6700.

Zhou, J., He, L., Liu, M., Guo, X., Du, G., Yan, L., Zhang, Z., Zhong, Z., and Chen, H. (2023). Sleep loss impairs intestinal stem cell function and gut homeostasis through the modulation of the GABA signalling pathway in Drosophila. Cell Prolif, e13437.

Huang, J., Sheng, X., Zhuo, Z., Xiao, D., Wu, K., Wan, G., and Chen, H. (2022). ClC-c regulates the proliferation of intestinal stem cells via the EGFR signalling pathway in Drosophila. Cell Prolif 55, e13173.

Wu K, Tang Y, Zhang Q, Zhuo Z, Sheng X, Huang J, Ye J, Li X, Liu Z, Chen H. (2021) Aging-related upregulation of the homeobox gene caudal represses intestinal stem cell differentiation in Drosophila. PLoS Genet 17(7): e1009649.

Du G., Liu Z., Yu Z., Zhuo Z., Zhu Y., Zhou J., Li Y., Chen H. (2021), Taurine represses age-associated gut hyperplasia in Drosophila via counteracting endoplasmic reticulum stress. Aging Cell 9;e13319.

Du, G., Qiao, Y., Zhuo, Z., Zhou, J., Li, X., Liu, Z., Li, Y., and Chen, H. (2020). Lipoic Acid Rejuvenates Aged Intestinal Stem Cells by Preventing Age-associated Endosome Reduction. EMBO Reports 21(8):e49583.

Du, G., Xiong, L., Li, X., Zhuo, Z., Zhuang, X., Yu, Z., Wu, L., Xiao, D., Liu, Z., Jie, M., Liu, X., Luo, G., Guo, Z., Chen, H. (2020). Peroxisome Elevation Induces Stem Cell Differentiation and Intestinal Epithelial Repair. Dev Cell 53, 169-184 e111.

Chen, H., Zheng, X., Xiao, D., and Zheng, Y. (2016). Age-associated de-repression of retrotransposons in the Drosophila fat body, its potential cause and consequence. Aging Cell 15, 542-552.

Chen, H., Zheng, X., and Zheng, Y. (2014). Age-associated loss of lamin-B leads to systemic inflammation and gut hyperplasia. Cell 159, 829-843.

Chen, H., Chen, X., and Zheng, Y. (2013). The nuclear lamina regulates germline stem cell niche organization via modulation of EGFR signaling. Cell Stem Cell 13, 73-86.