作为课题负责人先后承担国家自然科学基金面上项目5项，国家科技部863子课题和重大新药创制项目子课题各1项，四川省科技厅重点研发项目1项；作为第一主研参加国家自然科学基金重点项目和面上项目多项。目前主要从事糖尿病及其并发症发病与干预研究，已在Acta Biomater，Stem Cells，J Control Release，Cell Death and Disease，FASEB J等高水平国际期刊以第一作者/通讯作者发表论文60余篇，参编科学出版社出版和高教出版社的研究生教材各1本；以第一发明人申报获授权国家发明专利2项、美国发明专利1项、PCT专利1项。代表论文（通讯作者）：
1. Macrophage‐derived exosomal miR‐195a‐5p impairs tubular epithelial cells mitochondria in acute kidney injury mice. FASEB J. 2023 Jan; 37(1): e22691. doi:10.1096/fj. 202200644R.
2.miR-140-5p protects cartilage progenitor/stem cells from fate changes in knee osteoarthritis. International Immunopharmacology 114 (2023) 109576 . https://doi.org/10.1016/j.intimp.2022.109576
3.Molecular mechanisms and physiological functions of autophagy in kidney diseases. Frontiers in Pharmacology 2022 Aug 11;13:974829.doi: 10.3389/fphar.2022.974829. eCollection 2022.
4. Injectable self-assembling peptide nanofiber hydrogel as a bioactive 3D platform to promote chronic wound tissue regeneration. Acta Biomater. 2021, S1742-7061(21)00528-6
5.Mitochondrial transfer from MSCs to macrophages restricts inflammation and alleviates kidney injury in diabetic nephropathy mice via PGC-1ɑ activation. Stem Cells 2021, DOI: 10.1002/stem.3375
6.Macrophage-derived extracellular vesicles: Diverse mediators of pathology and therapeutics in multiple diseases. Cell Death and Disease 2020, 11, 924. https://doi.org/10.1038/s41419-020-03127-z.
7.Activation of TFEB-mediated autophagy by trehalose attenuates mitochondrial dysfunction in cisplatin-induced acute kidney injury. Theranostics 2020; 10(13): 5829-5844. doi: 10.7150/thno.44051
8.Mesenchymal stem cells elicit macrophages into M2 phenotype via improving transcription factor EB-mediated autophagy to alleviate diabetic nephropathy. Stem Cells 2020;38(5): 639-652. DOI: 10.1002/stem.3144
9.Phloretin ameliorates hyperuricemia-induced chronic renal dysfunction through inhibiting NLRP3 inflammasome activation and uric acid reabsorption. Phytomedicine 66, January 2020, 66:153111
Intervention for early diabetic nephropathy by Mesenchymal Stem Cells in a preclinical nonhuman primate model. Stem Cell Research & Therapy (2019)10:363. https://doi.org/10.1186/s13287- 019-1401-z
